Protein Name:
Sorbitol dehydrogenase
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UniprotKB/SwissProt ID: Q64442 (Q64442)
Gene Name:
Sord
Organism: Mus musculus (Mouse)
Function: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose (PubMed:6852349). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation (PubMed:18799757). Has no activity on ethanol. Cannot use NADP(+) as the electron acceptor (PubMed:6852349)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion membrane. Cell projection, cilium, flagellum
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q64442
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
179 |
SVSLGNKVLV C GAGPVGMVTL |
CCCCCCCCCE E EEEECCCCCE |
2.43% |
22178444
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| 2 |
350 |
KGVGLKVMIK C DPNDQNP--- |
CCCCCCCCCE E EEEECCCCCE |
7.91% |
22178444
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