UniprotKB/SwissProt ID: Q64435 (Q64435)
Gene Name:
Ugt1a6
Organism: Mus musculus (Mouse)
Function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body (PubMed:8068691). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:8068691). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE (By similarity). Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate (PubMed:8068691). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Microsome. Endoplasmic reticulum membrane
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