UniprotKB/SwissProt ID: Q64264 (Q64264)
Gene Name:
Htr1a
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:11080193, PubMed:17543467, PubMed:18599790, PubMed:21508226, PubMed:8254366, PubMed:9826725). Also functions as a receptor for various drugs and psychoactive substances (PubMed:11080193, PubMed:17543467, PubMed:18599790, PubMed:21508226, PubMed:8254366, PubMed:9826725). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, dendrite
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