UniprotKB/SwissProt ID: Q640N2 (Q640N2)
Gene Name:
Arl13b
Organism: Mus musculus (Mouse)
Function: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling (PubMed:23817546). Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex (PubMed:23153492). Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis (By similarity). May regulate ARF6- and RAB22A-dependent endocytic recycling traffic (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, cilium membrane. Cell projection, cilium
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