UniprotKB/SwissProt ID: Q63959 (Q63959)
Gene Name:
Kcnc3
Organism: Mus musculus (Mouse)
Function: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:15217387, PubMed:18539595, PubMed:24218544, PubMed:26997484). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells (PubMed:15217387, PubMed:18448641, PubMed:24218544). Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (PubMed:24218544). Required for normal motor function (PubMed:16923152, PubMed:18448641). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Presynaptic cell membrane. Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine membrane. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton
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