Protein Name:
Dual specificity mitogen-activated protein kinase kinase 2
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UniprotKB/SwissProt ID: Q63932 (Q63932)
Gene Name:
Map2k2
Organism: Mus musculus (Mouse)
Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (PubMed:19219045). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Membrane
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Graphical Visualization of S-nitrosylation Sites:
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