UniprotKB/SwissProt ID: Q62997 (Q62997)
Gene Name:
Gfra1
Organism: Rattus norvegicus (Rat)
Function: Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8674117). GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:25242331, PubMed:8674117)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus, trans-Golgi network. Endosome. Endosome, multivesicular body
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