Protein Name:
PDZ and LIM domain protein 5
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UniprotKB/SwissProt ID: Q62920 (Q62920)
Gene Name:
Pdlim5
Organism: Rattus norvegicus (Rat)
Function: May play an important role in the heart development by scaffolding PKC to the Z-disk region (PubMed:20097676, PubMed:8940095). May play a role in the regulation of cardiomyocyte expansion (PubMed:20097676). Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1 (PubMed:20097676). Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons (PubMed:20097676). May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation (PubMed:19900557)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Postsynaptic density. Presynapse. Postsynapse. Cytoplasm, cytosol. Postsynaptic density. Presynapse. Postsynapse. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q62920
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
441 |
GKSWHPEEFN C AHCKNTMAYI |
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| 2 |
444 |
WHPEEFNCAH C KNTMAYIGFV |
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| 3 |
474 |
LCYEKFFAPE C GRCQRKILGE |
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| 4 |
73 |
HLEAQNKIKA C TGSLNMTLQR |
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