UniprotKB/SwissProt ID: Q62418 (Q62418)
Gene Name:
Dbnl
Organism: Mus musculus (Mouse)
Function: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Synapse. Perikaryon. Cell projection, neuron projection. Cell membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Golgi apparatus membrane. Cell projection, podosome. Early endosome. Cell projection, dendrite. Postsynaptic density
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