Protein Name:
Poly(rC)-binding protein 2
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UniprotKB/SwissProt ID: Q61990 (Q61990)
Gene Name:
Pcbp2
Organism: Mus musculus (Mouse)
Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:8208614, PubMed:8367306). Major cellular poly(rC)-binding protein (By similarity). Also binds poly(rU) (By similarity). Acts as a negative regulator of antiviral signaling (By similarity). Negatively regulates cellular antiviral responses mediated by MAVS signaling (By similarity). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (By similarity). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (By similarity). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (PubMed:34180713)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q61990
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
109 |
TLRLVVPASQ C GSLIGKGGCK |
CCCCCCCCCE E EEEEEEHHHC |
3.56% |
22178444
19483679
20925432
21278135
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| 2 |
158 |
IAGIPQSIIE C VKQICVVMLE |
CCCCCCCCCE E EEEEEEHHHC |
3.06% |
22178444
19483679
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| 3 |
54 |
GARINISEGN C PERIITLAGP |
CCCCCCCCCE E EEEEEEHHHC |
5.64% |
20925432
21278135
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