Protein Name:
Pregnancy zone protein
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UniprotKB/SwissProt ID: Q61838 (Q61838)
Gene Name:
Pzp
Organism: Mus musculus (Mouse)
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q61838
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1339 |
NYVTKGSGSG C VYLQTSLKYN |
CCCCCCCCHH H HHHHHHCCCC |
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| 2 |
594 |
LKVKAAPLSL C ALTAVDQSVL |
CCCCCCCCHH H HHHHHHCCCC |
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22588120
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