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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: D-3-phosphoglycerate dehydrogenase

UniprotKB/SwissProt ID: Q61753 (Q61753)

Gene Name: Phgdh

Organism: Mus musculus (Mouse)

Function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029009 ASB_dom_sf
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR006236 PGDH
IPR045626 PGDH_ASB_dom

The S-nitrosylation sites of Q61753

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 18 KVLISDSLDP C CRKILQDGGL  CCCCCHHHHH H HCCCCHHHHH  3.32%
2 19 VLISDSLDPC C RKILQDGGLQ  CCCCCHHHHH H HCCCCHHHHH  6.37% 24926564
3 254 ALLRALQSGQ C AGAALDVFTE  CCCCCHHHHH H HCCCCHHHHH  4.26%
4 281 ALVDHENVIS C PHLGASTKEA  CCCCCHHHHH H HCCCCHHHHH  1.37%
5 369 QGTSLKNAGT C LSPAVIVGLL  CCCCCHHHHH H HCCCCHHHHH  3.28% 19101475
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