Protein Name:
Heat shock protein 105 kDa
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UniprotKB/SwissProt ID: Q61699 (Q61699)
Gene Name:
Hsph1
Organism: Mus musculus (Mouse)
Function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (PubMed:14644449, PubMed:15292236)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q61699
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
167 |
LDAAQIVGLN C LRLMNDMTAV |
CCEEEEECCC C EEEEEHHHCC |
2.55% |
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| 2 |
376 |
LNADEAVARG C ALQCAILSPA |
CCEEEEECCC C EEEEEHHHCC |
2.59% |
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| 3 |
380 |
EAVARGCALQ C AILSPAFKVR |
CCEEEEECCC C EEEEEHHHCC |
2.37% |
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| 4 |
642 |
RNDAKNAVEE C VYEFRDKLCG |
CCEEEEECCC C EEEEEHHHCC |
2.21% |
20925432
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| 5 |
659 |
KLCGPYEKFI C EQEHEKFLRL |
CCEEEEECCC C EEEEEHHHCC |
5.06% |
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| 6 |
797 |
RAKVKELNNV C EPVVTQPKPK |
CCEEEEECCC C EEEEEHHHCC |
5.49% |
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