Protein Name:
Chromobox protein homolog 5
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UniprotKB/SwissProt ID: Q61686 (Q61686)
Gene Name:
Cbx5
Organism: Mus musculus (Mouse)
Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (By similarity). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (By similarity). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (By similarity). Required for the formation of the inner centromere (By similarity) Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome. Chromosome, centromere
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q61686
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
160 |
LVLAKEANVK C PQIVIAFYEE |
CCCCCCCCCC C CCCCCHHHHH |
2.33% |
20925432
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| 2 |
59 |
NTWEPEKNLD C PELISEFMKK |
CCCCCCCCCC C CCCCCHHHHH |
2.96% |
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