Protein Name:
Glutamate receptor ionotropic, delta-2
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UniprotKB/SwissProt ID: Q61625 (Q61625)
Gene Name:
Grid2
Organism: Mus musculus (Mouse)
Function: Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand (PubMed:24357660). Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex (By similarity). In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine (PubMed:34936451). However, recent research disputes this ligand-gated cation channel activity (PubMed:39052831). Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells (PubMed:24357660, PubMed:27276689)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Postsynaptic cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q61625
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
131 |
RSTAGTPRSG C GLTRSNRNDD |
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