Protein Name:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
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UniprotKB/SwissProt ID: Q61425 (Q61425)
Gene Name:
Hadh
Organism: Mus musculus (Mouse)
Function: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (PubMed:20670938). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (PubMed:36398584) Inhibits cell proliferation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix. Nucleus. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q61425
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
201 |
QKTFESLVDF C KTLGKHPVSC |
CCHHHHHHHH H CCCCCCHHHH |
2.59% |
21278135
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| 2 |
211 |
CKTLGKHPVS C KDTPGFIVNR |
CCHHHHHHHH H CCCCCCHHHH |
4.75% |
21278135
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| 3 |
99 |
GDEFVEKTLS C LSTSTDAASV |
CCHHHHHHHH H CCCCCCHHHH |
3.8% |
21278135
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