UniprotKB/SwissProt ID: Q61153 (Q61153)
Gene Name:
Dio1
Organism: Mus musculus (Mouse)
Function: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:18821722, PubMed:32718224). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via outer-ring deiodination (ORD) (PubMed:32718224, PubMed:18339710). Catalyzes the deiodination of T4 to rT3, 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), T3 to 3,3'-T2 and 3,3'-T2 to 3-T1 via inner-ring deiodination (IRD) (PubMed:18821722, PubMed:32718224). Catalyzes the deiodiantion of 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via ORD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine (PubMed:18339710). Catalyzes the deiodination of L-thyroxine sulfate and 3,3',5-triiodo-L-thyronine sulfate via IRD and of 3,3',5'-triiodo-L-thyronine sulfate via ORD (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endoplasmic reticulum membrane. Basolateral cell membrane
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