Protein Name:
Ceruloplasmin
|
UniprotKB/SwissProt ID: Q61147 (Q61147)
Gene Name:
Cp
Organism: Mus musculus (Mouse)
Function: Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (By similarity). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:29183916)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q61147
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
694 |
PDTKGTFDVE C LTTDHYTGGM |
|
|
|
|
