Protein Name:
Atypical kinase COQ8A, mitochondrial
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UniprotKB/SwissProt ID: Q60936 (Q60936)
Gene Name:
Coq8a
Organism: Mus musculus (Mouse)
Function: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:27499294). Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (By similarity). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication (By similarity). Shows an unusual selectivity for binding ADP over ATP (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q60936
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
265 |
ANAERIVSTL C KVRGAALKLG |
CCHHHHHHHH H HHHHHHHHHH |
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21278135
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| 2 |
403 |
DVLRRELTLE C DYQREAAYAK |
CCHHHHHHHH H HHHHHHHHHH |
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21278135
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| 3 |
617 |
HRKMGGSFLI C SKLKARFPCK |
CCHHHHHHHH H HHHHHHHHHH |
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21278135
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| 4 |
638 |
AMFEEAYSNY C RMKSGLQ--- |
CCHHHHHHHH H HHHHHHHHHH |
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21278135
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