Protein Name:
Non-selective voltage-gated ion channel VDAC2
|
UniprotKB/SwissProt ID: Q60930 (Q60930)
Gene Name:
Vdac2
Organism: Mus musculus (Mouse)
Function: Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10430654). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (By similarity). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:10430654). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:34799735). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity) Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q60930
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
104 |
GTEIAIEDQI C QGLKLTFDTT |
CCCCEECCCC C CEECCCCCCH |
1.87% |
24895380
21278135
|
| 2 |
48 |
LVKLDVKTKS C SGVEFSTSGS |
CCCCEECCCC C CEECCCCCCH |
4.35% |
24895380
21278135
|
| 3 |
77 |
SGTLETKYKW C EYGLTFTEKW |
CCCCEECCCC C CEECCCCCCH |
2.23% |
24895380
22588120
21278135
|
|
