UniprotKB/SwissProt ID: Q60714 (Q60714)
Gene Name:
Slc27a1
Organism: Mus musculus (Mouse)
Function: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (Probable) (PubMed:10471110, PubMed:11970897, PubMed:12235169, PubMed:15699031, PubMed:19527715, PubMed:24858472, PubMed:28178239, PubMed:7954810, PubMed:9671728, PubMed:9786857). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10593920, PubMed:12235169, PubMed:12937175). May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation (PubMed:14991074, PubMed:15897321). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:12235169). May be involved in regulation of cholesterol metabolism (PubMed:12235169). Probably involved in fatty acid transport across the blood barrier (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Mitochondrion outer membrane. Endomembrane system. Cytoplasm
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