UniprotKB/SwissProt ID: Q60700 (Q60700)
Gene Name:
Map3k12
Organism: Mus musculus (Mouse)
Function: Protein kinase which is part of a non-canonical MAPK signaling pathway (PubMed:28111074, PubMed:7983011, PubMed:8663324). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane
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