Protein Name:
2-oxoglutarate dehydrogenase complex component E1
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UniprotKB/SwissProt ID: Q60597 (Q60597)
Gene Name:
Ogdh
Organism: Mus musculus (Mouse)
Function: 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC. Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids. Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate. Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q60597
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
283 |
SSEKRFGLEG C EVLIPALKTI |
CCCCCCHHHH H CCCCHHHCHH |
2.09% |
21278135
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| 2 |
331 |
VIRKELEQIF C QFDSKLEAAD |
CCCCCCHHHH H CCCCHHHCHH |
4.15% |
21278135
|
| 3 |
395 |
MGKTKAEQFY C GDTEGKKVMS |
CCCCCCHHHH H CCCCHHHCHH |
4.14% |
21278135
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| 4 |
487 |
SDDPEAVMYV C KVAAEWRNTF |
CCCCCCHHHH H CCCCHHHCHH |
1.29% |
21278135
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| 5 |
507 |
FHKDVVVDLV C YRRNGHNEMD |
CCCCCCHHHH H CCCCHHHCHH |
2.58% |
21278135
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| 6 |
566 |
EEEISKYDKI C EEAFTRSKDE |
CCCCCCHHHH H CCCCHHHCHH |
4.81% |
21278135
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| 7 |
604 |
TLDGQPRSMT C PSTGLEEDVL |
CCCCCCHHHH H CCCCHHHCHH |
1.55% |
21278135
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| 8 |
832 |
LYDCNWIVVN C STPGNFFHVL |
CCCCCCHHHH H CCCCHHHCHH |
3.03% |
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| 9 |
904 |
DPHKVKRLLF C TGKVYYDLTR |
CCCCCCHHHH H CCCCHHHCHH |
5.04% |
21278135
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| 10 |
956 |
QKYPNAELAW C QEEHKNQGYY |
CCCCCCHHHH H CCCCHHHCHH |
2.8% |
21278135
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