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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: F-actin-capping protein subunit beta

UniprotKB/SwissProt ID: Q5XI32 (Q5XI32)

Gene Name: Capzb

Organism: Rattus norvegicus (Rat)

Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR037282 CapZ_alpha/beta
IPR042276 CapZ_alpha/beta_2
IPR001698 CAPZB
IPR043175 CAPZB_N
IPR019771 F-actin_capping_bsu_CS

The S-nitrosylation sites of Q5XI32

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 206 QMEKDETVSD C SPHIANIGRL   
2 62 DKVVGKDYLL C DYNRDGDSYR