Protein Name:
F-actin-uncapping protein LRRC16A
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UniprotKB/SwissProt ID: Q5VZK9 (Q5VZK9)
Gene Name:
CARMIL1
Organism: Homo sapiens (Human)
Function: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5VZK9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1004 |
KKQQPTQAAV C AANIVSQDGE |
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| 2 |
235 |
SKDLKLSTDV C EQILRVVSRS |
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| 3 |
464 |
LKGVSLDLSN C ELRSGGAQVL |
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