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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: DENN domain-containing protein 4C

UniprotKB/SwissProt ID: Q5VZ89 (Q5VZ89)

Gene Name: DENND4C

Organism: Homo sapiens (Human)

Function: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR043153 DENN_C
IPR051696 DENN_Domain_GEFs
IPR023341 MABP
IPR011990 TPR-like_helical_dom_sf
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The S-nitrosylation sites of Q5VZ89

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1211 LDPLSLLATE C TGGKTPDSED