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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Threonylcarbamoyladenosine tRNA methylthiotransferase

UniprotKB/SwissProt ID: Q5VV42 (Q5VV42)

Gene Name: CDKAL1

Organism: Homo sapiens (Human)

Function: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR006638 Elp3/MiaA/NifB-like_rSAM
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR006466 MiaB-like_arc_euk
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom

The S-nitrosylation sites of Q5VV42

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 138 EENKKIVLAG C VPQAQPRQDY   
2 338 SVLMEMKREY C VADFKRVVDF   
3 556 VLPMPRLHQD C ALRMSVGLAL