Protein Name:
Mitochondrial amidoxime-reducing component 1
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UniprotKB/SwissProt ID: Q5VT66 (Q5VT66)
Gene Name:
MTARC1
Organism: Homo sapiens (Human)
Function: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:19053771, PubMed:21029045)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5VT66
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
273 |
ELKRVMACSR C ILTTVDPDTG |
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