Protein Name:
Vacuolar protein sorting-associated protein 53 homolog
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UniprotKB/SwissProt ID: Q5VIR6 (Q5VIR6)
Gene Name:
VPS53
Organism: Homo sapiens (Human)
Function: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5VIR6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
365 |
EGFLAKRFSG C TLTDGTLKKL |
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