Protein Name:
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
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UniprotKB/SwissProt ID: Q5U367 (Q5U367)
Gene Name:
Plod3
Organism: Rattus norvegicus (Rat)
Function: Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens. Essential for normal formation of basement membranes (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Rough endoplasmic reticulum. Endoplasmic reticulum lumen. Endoplasmic reticulum membrane. Secreted. Secreted, extracellular space
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5U367
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
694 |
HKGVDYEGGG C RFLRYDCRVS |
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