Protein Name:
Ubiquitin-like modifier-activating enzyme 1
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UniprotKB/SwissProt ID: Q5U300 (Q5U300)
Gene Name:
Uba1
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5U300
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
481 |
YFLVGAGAIG C ELLKNFAMIG |
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| 2 |
632 |
QDPPEKSIPI C TLKNFPNAIE |
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