Protein Name:
ATP-dependent RNA helicase DDX39A
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UniprotKB/SwissProt ID: Q5U216 (Q5U216)
Gene Name:
Ddx39a
Organism: Rattus norvegicus (Rat)
Function: Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5U216
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
164 |
KKDEDVLKKN C PHVVVGTPGR |
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| 2 |
197 |
RNVKHFVLDE C DKMLEQLDMR |
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