Protein Name:
SH3 and PX domain-containing protein 2A
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UniprotKB/SwissProt ID: Q5TCZ1 (Q5TCZ1)
Gene Name:
SH3PXD2A
Organism: Homo sapiens (Human)
Function: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell projection, podosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5TCZ1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
749 |
DADANAGLTS C PRAKPSVRPK |
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