Protein Name:
BEN domain-containing protein 3
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UniprotKB/SwissProt ID: Q5T5X7 (Q5T5X7)
Gene Name:
BEND3
Organism: Homo sapiens (Human)
Function: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5T5X7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
119 |
GNVWPGEEEP C NDATTPSYKK |
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| 2 |
597 |
THENLRKQYN C SGSLGKKQLD |
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| 3 |
767 |
LRLQYNHSGA C NKKQLDPTRL |
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