Protein Name:
Transmembrane protein 201
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UniprotKB/SwissProt ID: Q5SNT2 (Q5SNT2)
Gene Name:
TMEM201
Organism: Homo sapiens (Human)
Function: Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860) May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus inner membrane. Nucleus inner membrane. Cytoplasm, cytoskeleton, spindle pole
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5SNT2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
626 |
TCVVDTTTRG C SEEAATWRGR |
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