Protein Name:
Pannexin-1
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UniprotKB/SwissProt ID: Q5REE3 (Q5REE3)
Gene Name:
PANX1
Organism: Pongo abelii (Sumatran orangutan)
Function: Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (By similarity). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity) During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5REE3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
347 |
ENISEVKSYK C LKVLENIKSS |
CCHHHHHHHH H HHHHHCCCCC |
3.18% |
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| 2 |
40 |
LELAVDKMVT C IAVGLPLLLI |
CCHHHHHHHH H HHHHHCCCCC |
0.97% |
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