UniprotKB/SwissProt ID: Q5R764 (Q5R764)
Gene Name:
CXADR
Organism: Pongo abelii (Sumatran orangutan)
Function: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Basolateral cell membrane. Cell junction, tight junction. Cell junction, adherens junction
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