UniprotKB/SwissProt ID: Q5NCQ5 (Q5NCQ5)
Gene Name:
Dph1
Organism: Mus musculus (Mouse)
Function: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:24895408). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor (PubMed:14744934, PubMed:15661533, PubMed:24895408)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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