Protein Name:
PCI domain-containing protein 2
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UniprotKB/SwissProt ID: Q5JVF3 (Q5JVF3)
Gene Name:
PCID2
Organism: Homo sapiens (Human)
Function: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, nuclear pore complex
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5JVF3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
148 |
LEKAAELLMS C FRVCASDTRA |
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| 2 |
240 |
EEYLSFAFEH C HRSSQKNKRM |
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| 3 |
25 |
EAIDSRDGAS C AELVSFKHPH |
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| 4 |
399 |
QNPFPPLSTV C ---------- |
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| 5 |
50 |
RLQMASPEEK C QQVLEPPYDE |
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| 6 |
68 |
YDEMFAAHLR C TYAVGNHDFI |
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