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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glycine--tRNA ligase
UniprotKB/SwissProt ID: Q5I0G4 (Q5I0G4)

Gene Name: Gars1

Organism: Rattus norvegicus (Rat)

Function: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Mitochondrion. Cell projection, axon. Secreted. Secreted, extracellular exosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR045864 aa-tRNA-synth_II/BPL/LPL
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR027031 Gly-tRNA_synthase/POLG2
IPR033731 GlyRS-like_core
IPR002315 tRNA-synt_gly
IPR009068 uS15_NS1_RNA-bd_sf
IPR000738 WHEP-TRS_dom
The S-nitrosylation sites of Q5I0G4
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 200 FMVKDVKNGE C FRADHLLKAH   
2 450 TSYGWIEIVG C ADRSCYDLSC   
3 455 IEIVGCADRS C YDLSCHARAT   
4 460 CADRSCYDLS C HARATKVPLV