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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Probable E3 ubiquitin-protein ligase HERC4

UniprotKB/SwissProt ID: Q5GLZ8 (Q5GLZ8)

Gene Name: HERC4

Organism: Homo sapiens (Human)

Function: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR051709 Ub-ligase/GTPase-reg

The S-nitrosylation sites of Q5GLZ8

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1025 GEEYLPVSHT C FNLLDLPKYT   
2 124 GQLGLVGSEE C IRVPRNIKSL   
3 160 LALSKASEVF C WGQNKYGQLG   
4 175 KYGQLGLGTD C KKQTSPQLLK   
5 248 SLRSQKIVYI C CGEDHTAALT   
6 41 FINKRVRDVG C GLRHTVFVLD