Protein Name:
Ras-related protein Rab-18
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UniprotKB/SwissProt ID: Q5EB77 (Q5EB77)
Gene Name:
Rab18
Organism: Rattus norvegicus (Rat)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Also required for maintaining endoplasmic reticulum structure (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus, cis-Golgi network membrane. Lipid droplet. Apical cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q5EB77
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
155 |
MLFIEASAKT C DGVQCAFEEL |
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| 2 |
160 |
ASAKTCDGVQ C AFEELVEKII |
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