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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Syntaxin-binding protein 5-like

UniprotKB/SwissProt ID: Q5DQR4 (Q5DQR4)

Gene Name: Stxbp5l

Organism: Mus musculus (Mouse)

Function: Plays a role in vesicle trafficking and exocytosis inhibition (PubMed:25002582). In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane (PubMed:21998599). Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (PubMed:24744148). Promotes as well axonal outgrowth (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane. Membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR042855 V_SNARE_CC
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR019775 WD40_repeat_CS
IPR036322 WD40_repeat_dom_sf
IPR001680 WD40_rpt

The S-nitrosylation sites of Q5DQR4

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 608 SEGVTKDSIP C LSVKTRPVRM