Protein Name:
WD repeat-containing protein 81
|
UniprotKB/SwissProt ID: Q562E7 (Q562E7)
Gene Name:
WDR81
Organism: Homo sapiens (Human)
Function: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Mitochondrion. Cytoplasm, cytosol
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q562E7
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
215 |
GPCPPRGSPA C PSLLRAEALL |
|
|
|
|
