Protein Name:
Pyrroline-5-carboxylate reductase 3
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UniprotKB/SwissProt ID: Q53H96 (Q53H96)
Gene Name:
PYCR3
Organism: Homo sapiens (Human)
Function: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H (PubMed:23024808, PubMed:36414121). Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs) (PubMed:23024808). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine (PubMed:23024808)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q53H96
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
RVLRVLPNLP C VVQEGAIVMA |
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| 2 |
235 |
QHPAQLRSDV C TPGGTTIYGL |
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| 3 |
266 |
ATMSAVEAAT C RAKELSRK-- |
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| 4 |
49 |
LASAPTDRNL C HFQALGCRTT |
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