Protein Name:
Programmed cell death protein 4
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UniprotKB/SwissProt ID: Q53EL6 (Q53EL6)
Gene Name:
PDCD4
Organism: Homo sapiens (Human)
Function: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q53EL6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
227 |
EMTSKLLSDL C GTVMSTTDVE |
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| 2 |
275 |
IARAVGDGIL C NTYIDSYKGT |
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| 3 |
288 |
YIDSYKGTVD C VQARAALDKA |
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| 4 |
350 |
LSGDISEAEH C LKELEVPHFH |
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| 5 |
433 |
YSVLERFVEE C FQAGIISKQL |
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