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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Rho GTPase-activating protein 29

UniprotKB/SwissProt ID: Q52LW3 (Q52LW3)

Gene Name: ARHGAP29

Organism: Homo sapiens (Human)

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027267 AH/BAR_dom_sf
IPR046349 C1-like_sf
IPR031160 F_BAR
IPR054713 GMIP/FCHO2-like_FCH
IPR002219 PE/DAG-bd
IPR057028 RHG29_45_N
IPR008936 Rho_GTPase_activation_prot
IPR051025 RhoGAP
IPR000198 RhoGAP_dom

The S-nitrosylation sites of Q52LW3

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1215 SMPDPDKASA C PGQATGQPKE   
2 518 DSSNKIEEDR C SNSADITGPS