UniprotKB/SwissProt ID: Q505I0 (Q505I0)
Gene Name:
pi4k2a
Organism: Xenopus tropicalis (Western clawed frog)
Function: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, trans-Golgi network membrane. Membrane raft. Endosome. Endosome membrane. Cytoplasmic vesicle. Cell projection, dendrite. Presynaptic cell membrane. Synapse, synaptosome. Mitochondrion. Membrane. Cell membrane. Perikaryon. Cell projection, neuron projection
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