UniprotKB/SwissProt ID: Q4VCS5 (Q4VCS5)
Gene Name:
AMOT
Organism: Homo sapiens (Human)
Function: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, tight junction
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