UniprotKB/SwissProt ID: Q4V4I9 (Q4V4I9)
Gene Name:
CCHa1
Organism: Drosophila melanogaster (Fruit fly)
Function: Neuropeptide ligand for the CCHamide-1 receptor CCHa1-R (PubMed:21110953, PubMed:23293632). Neuromessenger mediating signaling between neuronal cells of the circadian clock network involved in regulation of sleep latency (the time required to fall asleep), amount of sleep and depth of sleep (arousability) (PubMed:30246807, PubMed:36958331). Together with PDF, involved in regulating intensity and periodicity of daytime activity (PubMed:36786215). In subsets of clock neurons modulates the rhythmic expression of PDP1 and PDF, and together with PDF modulates the rhythmic expression of circadian protein PER/period, but not TIM/timeless (PubMed:30246807, PubMed:36786215). Mediates signaling from DN1a (anterior dorsal neurons 1) clock neurons to s-LNv (small ventral lateral neurons) clock neurons through CCHa1-R, contributing to regulation of activity rhythms by the circadian clock, particularly in the morning (PubMed:30246807). May be involved in signaling between clock neurons and non-clock neurons, such as the fan-shaped body, involved in sleep homeostasis (PubMed:36786215). In response to a high protein diet mediates hormonal signaling between the gut and a CCHa1-R expressing subset of dopaminergic cells in the protocerebral anterior medial (PAM) cluster of the brain (PubMed:36958331). This suppresses arousability by mechano-sensory stimulation (but not thermal stimulation) but is not involved in regulation of sleep patterns (PubMed:36958331)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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